Blood Disorders Deep Vein Thrombosis Guide Deep Vein Thrombosis Guide Overview Symptoms Diagnosis Prevention How Deep Vein Thrombosis Is Diagnosed By Richard N. Fogoros, MD Updated on October 30, 2022 Medically reviewed by Douglas A. Nelson, MD Print Table of Contents View All Table of Contents Labs and Tests Imaging Differential Diagnoses Frequently Asked Questions Next in Deep Vein Thrombosis Guide Prevention of Deep Vein Thrombosis If a healthcare provider suspects a patient has deep vein thrombosis (DVT), a condition defined by a blood clot forming in one of the deep veins, they will attempt to make a definitive diagnosis as quickly as possible. There is a potential for such a blood clot to loosen and travel to the lungs, which can cause a potentially life-threatening pulmonary embolism (PE). Anyone who experiences symptoms of DVT should see a practitioner, who will likely perform an ultrasound if they suspect the condition. Other tests, such as a venogram, impedance plethysmography, CT scan, or a D-dimer test, may also be used to identify DVT and/or its cause. © Verywell Labs and Tests Your healthcare provider may order blood tests to determine if you have inherited a blood disorder associated with DVT and PE. The blood tests are also used to measure carbon dioxide and oxygen levels. A blood clot in the lungs can lower oxygen levels in the blood. A D-dimer test indicates whether you have elevated levels of D-dimer, a protein fragment that's left over from a clot once it's formed. If your D-dimer levels are elevated, it suggests that you may have a DVT, but there are other reasons for an elevated D-dimer; additional tests are required to confirm the presence of a DVT or PE. While the D-dimer generally has reliable results, it cannot identify where the blood clot is. The other drawbacks of the D-dimer test are that it may not be as reliable for finding clots in pregnant women, people who take blood thinners, and those with a history of DVT. Deep Vein Thrombosis Doctor Discussion Guide Get our printable guide for your next doctor's appointment to help you ask the right questions. Download PDF Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Email Address Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. Imaging While it's true signs and symptoms of DVT can mimic those of other conditions, if DVT is a possibility, a healthcare provider will undoubtedly opt for imaging tests to get to the bottom of things. Ultrasound This is typically the preferred option for diagnosis. There are different types of venous ultrasonography: Duplex ultrasound (B-mode imaging and Doppler waveform analysis): Duplex ultrasonography uses high-frequency sound waves to visualize the flow of blood in the veins. It can detect blood clots in the deep veins and is one of the quickest, most painless, reliable, and noninvasive ways to diagnose DVT. The duplex ultrasonography also includes a color-flow Doppler analysis.Compression ultrasound (B-mode imaging): Similar to duplex ultrasonography, compression ultrasound is a variation of the commonly-used echocardiogram test (also known as an “echo”). A probe uses sound waves to construct an image of the tissue that lies beneath. The technician performing the ultrasound can then attempt to compress the vein by pushing on it with the ultrasound probe in the femoral vein (in the groin area) or the popliteal vein (behind the knee). Veins are typically highly compressible, which means they can be collapsed temporarily by applying pressure to them. But if DVT is present, a blood clot makes it difficult to compress the vein. A non-compressible vein is almost always an indication a DVT is present. The ultrasound technique can also be used to visualize the clot itself and to assess whether there's an obstruction of blood flow through the vein.Color Doppler imaging: This produces a 2-D image of the blood vessels. With a Doppler analysis, a healthcare provider can see the structure of the vessels, where the clot is located, and the blood flow. The Doppler ultrasound can also estimate how quickly blood is flowing and reveal where it slows down and stops. As the transducer is moved, it creates an image of the area. The reliability of these tests varies. For example, compression ultrasounds are best for detecting DVT in proximal deep veins, like femoral and popliteal veins (thighs), but duplex ultrasound and color Doppler imaging are best for DVT of the calf and iliac veins (pelvis). Venogram In the past, making a firm diagnosis of DVT required performing a venogram. With a venogram, a contrast iodine-based dye is injected into a large vein in the foot or ankle, so healthcare providers can see the veins in the legs and hips. X-ray images are made of the dye flowing through the veins toward the heart. This allows for practitioners and medical professionals to see major obstructions to the leg vein. This invasive test can be painful and entails certain risks, such as infection, so practitioners generally prefer to use the duplex ultrasonography method. However, some healthcare providers will use a venogram for people who have had a history of DVT. Because blood vessels and veins in these individuals are likely damaged from previous clots, a duplex ultrasonography won't be able to detect a new clot like a venogram can. Some healthcare providers use magnetic resonance (MR) venography instead of the X-ray version because it's less invasive. The MR machine uses radio frequency waves to line up hydrogen atoms within tissues. When the pulse stops, the hydrogen atoms return to their normal state, giving off one type of signal for tissues in the body and another for blood clots. The MR machine uses these to create an image that allows medical professionals to discern between the two. MRI and CT Scans Magnetic resonance imaging (MRI) and computed tomography (CT) scans can create images of the organs and tissues in the body, as well as veins and clots. While useful, they are generally used in conjunction with other tests to diagnose DVT. If your healthcare provider suspects you have a pulmonary embolism (PE), they may opt for a computed tomographic pulmonary angiography (CTPA)—a test in which a contrast dye is injected into the arm. The dye travels through the blood vessels leading to the lungs to create clear images of the blood flow to the lungs in the images produced. Lung Ventilation-Perfusion Scans; Pulmonary Angiography If a CPTA isn't available, you might get a lung ventilation-perfusion scan or a pulmonary angiography test. With the lung ventilation-perfusion scan, a radioactive substance shows the blood flow and oxygenation of the lungs. If you have a blood clot, the scan might show normal amounts of oxygen but slowed blood flow in parts of the lungs that have clotted vessels. With a pulmonary angiography test, a catheter from the groin injects a contrast dye into the blood vessels, which allows healthcare providers to take X-ray images and follow the path of the dye to check for blockages. Impedance Plethysmography Impedance plethysmography is another non-invasive test for diagnosing DVT. While this test is reliable, many hospitals do not have the equipment or the expertise readily available to perform this test efficiently. In impedance plethysmography, a cuff (similar to a blood pressure cuff) is placed around the thigh and inflated in order to compress the leg veins. The volume of the calf is then measured (by means of electrodes that are placed there). When the cuff deflates, it allows the blood that had been "trapped" in the calf to flow out through the veins. The calf volume measurement is then repeated. If DVT is present, the difference in volume (with the cuff inflated versus deflated) will be less than normal, indicating that the veins are partially obstructed by a blood clot. Differential Diagnoses Test results and a physical exam can help rule out (or in) other possible causes of your symptoms. A few that will be considered: Insufficient circulation (venous insufficiency) A blood clot close to the surface of the skin (superficial thrombophlebitis) Muscle injury (strain, tear, or trauma) Baker's cyst Cellulitis Lymphedema Frequently Asked Questions Can a blood test detect a blood clot? A D-dimer is often used to rule out a clot. If it's abnormal, it indicates some form of activation of the clotting system, which may indicate a DVT. A D-dimer cannot be used to diagnose a blood clot, it can only suggest a blood clot in which case further tests are needed. How does a healthcare provider test for DVT? Imaging studies used to diagnose DVT include duplex ultrasound, venogram, and MRI. Can DVT go away on its own? Yes, DVT often goes unnoticed and the clot dissolves on its own. However, if it causes symptoms and is discovered, it should be treated to prevent serious complications such as a pulmonary embolism. What can mimic DVT? Other conditions that present similarly to DVT include venous insufficiency, superficial thrombophlebitis, a muscle strain, tear, or trauma, a Baker’s cyst, cellulitis, and lymphedema. 5 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Texas Heart Institute. Pulmonary embolism. Centers for Disease Control and Prevention. Diagnosis and treatment of venous thromboembolism. U.S. National Library of Medicine: MedlinePlus. D-dimer test. American Academy of Orthopedic Surgeons: OrthoInfo. Deep vein thrombosis. Institute for Quality and Efficiency in Health Care (IQWiG). Deep vein thrombosis (DVT): Overview. Additional Reading Crisp JG, Lovato LM, Jang TB. Compression ultrasonography of the lower extremity with portable vascular ultrasonography can accurately detect deep venous thrombosis in the emergency department. Ann Emerg Med. 2010 Dec. 56(6):601-10. doi:10.1016/j.annemergmed.2010.07.010 Stanford University Healthcare. Duplex ultrasound for CVI. The National Heart, Lung, and Blood Institute. Pulmonary embolism. By Richard N. Fogoros, MD Richard N. Fogoros, MD, is a retired professor of medicine and board-certified in internal medicine, clinical cardiology, and clinical electrophysiology. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit