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Hormone replacement - no effect on incidence of stroke
February 9, 2001

An article in this week's Circulation reports that hormone replacement with estrogen and progestin does not alter the incidence of stroke in postmenopausal women with coronary artery disease.  This data comes from the Heart Estrogen-progestin Replacement Study (HERS). While previous studies have given mixed results, many doctors had hoped that hormone replacement would be shown to reduce stroke risk.

Previous data from HERS showed that women with prior coronary artery disease had an increased risk of heart attack during the first year after hormone replacement therapy was begun, and a decreased risk afterwards.  Measuring the risk of stroke in these women was a secondary goal of the study.

Study investigators point out that the results of HERS do not rule out a beneficial effect for hormone replacement therapy in women without a prior history of coronary artery disease.  

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