Amiodarone (Cordarone) is both the most effective and the most toxic antiarrhythmic drug ever developed. It's range of toxicities is so odd and potentially so harmful that one might wonder how a drug like this ever got approved. As it turns out, the history of amiodarone - its development, its usage, and how the drug came to be used in the United States - is as strange as the drug itself. Click here for the whole, strange history of amiodarone.